About the Guest: Dr. Ryan Gumpper is a biochemist & biophysicist in Dr. Bryan Roth's lab at the University of North Carolina.
Episode Summary: Nick Jikomes talks to neuroscientist & Alex Gumpper, PhD about the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds with therapeutic benefits, as well as the inspiration Ryan received from reading Alexander Shulgin's famous book, PIHKAL.
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